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The UN MEDEVAC Mechanism serves as an example of a successful One UN partnership between numerous entities to design, resource, and implement a system-wide medical evacuation framework in the face of the unprecedented circumstances of the COVID-19 pandemic. Complementing First Line of Defense activities, COVID-19 MEDEVAC is a last resort which provides life-saving support for severely ill COVID-19 patients, who require a level of care not available at their location. This ensures that UN personnel, partners, and their dependents can continue to stay and deliver.